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July 25, 1925


JAMA. 1925;85(4):271-272. doi:10.1001/jama.1925.02670040035012

The bile pigments, G. H. Whipple1 wrote three years ago, may or may not be the most important components of the normal bile, but certain it is that they have received the largest amount of attention, clinical and experimental. Bile pigments appear in demonstrable amounts in the bile canaliculi of the normal or abnormal hepatic epithelial cell. It is therefore a bit too easy to think of the hepatic cell as the only essential factor in the elaboration of bile pigment. But it is well, Whipple concludes, for physician, teacher, student and investigator to keep clearly in mind that other body cells have the capacity rapidly to change hemoglobin to bile pigment.

No sooner is some striking evidence presented in support of one of the contending views as to the place of formation of bile pigments—for hepatic or nonhepatic origin, as the case may be—than a contradiction or a