The reaction of the mucous membrane lining the respiratory tract produces a characteristic clinical picture in a certain definite group of persons who exhibit an abnormal sensitivity to protein substances. Such individuals are separated from the normal by the appellation "allergic." As the work of Adkinson,1 Cooke and Vander Veer2 and Spain and Cooke3 shows, heredity is an important factor in explaining the existence of such a group of individuals, which may be estimated as consisting of about 10 per cent, of the population, a group sufficiently large to merit recognition, for undoubtedly its members come under the almost daily observation of the practitioner who limits his field to the nose and throat. Its proper recognition is dependent on a knowledge of the manifestations of allergic phenomena.
PINESS G, MILLER H. ALLERGY: A NONSURGICAL DISEASE OF THE NOSE AND THROAT. JAMA. 1925;85(5):339–341. doi:10.1001/jama.1925.02670050023008
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