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August 8, 1925


JAMA. 1925;85(6):454. doi:10.1001/jama.1925.02670060056027

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"Dysoxidative Carbonuria"  At the last meeting of the Society of Internal Medicine, Professor Bickel and Dr. Kauffmann-Cosla (Bucharest) reported investigations that they have been undertaking to establish a new disease entity: dysoxidative carbonuria. They have found that in diabetes, aside from the carbon contained in sugar and in fat derivatives (ketone bodies), frequently large quantities of other carbon compounds resulting from sugar metabolism are found in the urine. This carbon, which is more oxidized than carbohydrate but less so than carbon dioxid, can be made to disappear by the injection of proper quantities of insulin, just as sugar may be. The same thing was found to be true with reference to urinary carbons in avitaminoses.After the foregoing points had been established, Bickel and Kauffmann-Cosla examined other patients with a view to finding evidence of insufficiently oxidized carbon compounds in the urine and found them in a number of instances,

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