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A married woman, aged 25, was taken suddenly ill, at 11 a. m., with severe pain in the epigastrium. The pain was constant and radiated to the upper part of the back between the shoulder blades. Three hypodermic injections of morphin and chloroform were required for its relief. At 11:30 the leukocyte count was 16,000. At 2: 30 it was 20,000. During the day the patient vomited three times, and in the afternoon she had a chill. She began to complain of pain in the right shoulder and soreness all over the body except in the hands and feet. By late afternoon, she had an eruption about the neck, upper part of the chest, and shoulders. The morning of the second day, she had a dull pain in the epigastrium and general soreness over the abdomen. At 9:30 a. m. on the second day the leukocyte count had reached 34,000.
Kennedy JP. RUPTURED OVARIAN CYST WITH SERUM RASH. JAMA. 1925;85(7):517. doi:10.1001/jama.1925.26710070001014a
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