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August 22, 1925


Author Affiliations

Iowa City
From the Department of Pediatrics, State University of Iowa College of Medicine.

JAMA. 1925;85(8):580. doi:10.1001/jama.1925.26710080002008a

Diabetic children usually show symptoms of insulin shock when the blood sugar reaches a value of from 0.050 to 0.040 per cent Recently, however, we have observed two children whose venous blood sugars reached much lower values without any apparent signs of shock. The blood sugar was determined in all cases by the method of Folin and Wu,1 with the exception that dilutions to 6 or 12.5 c.c. were used when the sugar content was very low. Pfanstiehl's chemically pure special glucose was used in making the standards.

M. B., a girl, aged 4 years, showed on two occasions blood sugar values of 0.036 and 0.042 per cent., respectively, without any noticeable evidence of shock. With typical beginning insulin reaction—i. e., the child fully conscious, though drowsy, flushed, and perspiring freely, and unable to walk alone—the blood sugar was 0.025 per cent.

Similar observations were noted in the case