There is no field of medicine so difficult, and yet so widely exploited, as the chemotherapy of syphilis. The last few years have witnessed the introduction of a host of new drugs, arsenical, mercurial and bismuth preparations, designed to supplant existing methods of treatment. Unfortunately, these preparations have been only too often prematurely introduced on the basis of insufficient experimental evidence by overenthusiastic investigators, or worse, of unwarranted therapeutic claims made by unscrupulous manufacturers. As Stokes1 has recently pointed out, the average practitioner is not sufficiently familiar with the mechanism of drug action in syphilis to enable him to judge the value of new preparations, so that before a drug is made available for general distribution, all possible information regarding its use should be placed before the profession. For this reason the present paper will provide in detail the clinical results of the use of flumerin, the disodium salt
MOORE JE, WASSERMANN H. THE CLINICAL RESULTS WITH FLUMERIN IN SYPHILIS. JAMA. 1923;81(22):1840–1847. doi:10.1001/jama.1923.02650220010003
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