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The author describes five cases of ichthyosis congenita in syphilitic infants. In the first two cases, Spirochaeta pallida was demonstrated in the umbilical cord. In the last three cases the parents were both syphilitic. In the second case described, there was a blood relationship between the parents. The author discusses in detail the possible influence of the syphilitic infection in these cases, and also the question of consanguineous marriage. Following a detailed description of his cases covering his histologic findings, he gives an excellent review of previously reported literature; this is followed by a general discussion of possible etiology and pathogenesis, diagnosis, prognosis and treatment.
Studien über Ichthyosis congenita s. foetalis. JAMA. 1925;85(9):699. doi:10.1001/jama.1925.02670090055030
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