The earliest record found on the antenatal treatment of congenital syphilis was that of Bertin1 in 1810. Lancercaux,1 in 1868, admitted that, in his opinion, antenatal treatment was the correct method of procedure; but there still existed, at that time, a well recognized school which taught that it was both wrong and dangerous. The treatment at that time consisted in the administration of mercury in some form plus the free use of potassium iodid. This method of treatment had only a slight degree of success. Since the introduction of arsphenamin, the antenatal treatment of congenital syphilis with arsenic and mercury has had a surprising degree of success. Greenlees2 and Findlay3 report complete success in their series of cases, which, although few in number (fifteen), contained some that have been followed for a period of seven years. Fordyce and Rosen4 have obtained excellent results after adequate
UNDERHILL FP, AMATRUDA FG. THE TRANSMISSION OF ARSENIC FROM MOTHER TO FETUS. JAMA. 1923;81(24):2009–2012. doi:10.1001/jama.1923.02650240013004
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