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December 15, 1923


JAMA. 1923;81(24):2035. doi:10.1001/jama.1923.02650240039017

With the growing victory over communicable diseases and the decrease in mortality from such causes, there has come a belief that the chronic or regressive class of diseases—those involving the circulatory system and the kidneys and affecting chiefly persons in middle life and old age—has increased in prominence. Nephritis belongs in the latter group. Always a serious menace, the disease, or the category of maladies which the designation represents, has baffled the attempts to gain a clear insight into its etiology. He would be rash, indeed, who ventured to assert that even the fundamental causative features have been established beyond conjecture. Yet in the United States alone tens of thousands of deaths officially charged to nephritis challenge investigation and critical contemplation of the large mass of data accumulated since Richard Bright set apart the nonsuppurative affection of the kidney as a clinical entity.

The complicity of bacteria in the genesis