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Since the advent of the intensive methods of treating syphilis, reports of second infection with this disease have been of comparative frequency. However, no report of a third infection has come to my notice, and a search of the available literature has failed to find such a report. Therefore this case seems of interest.
A. J., a man, aged 32, first consulted me, April 25, 1916, complaining of a sore on the penis. The family and past history, with the exception of the venereal history, were unimportant. He stated that he had had a sore on the penis in 1911, which was diagnosed clinically as a syphilitic chrancre and for which he received one intramuscular injection of arsphenamin. He denied any further evidences of or treatment for syphilis.
Examination revealed an eroded, circular lesion about 1 cm. in diameter on the dorsum of the penis about 2 or 3 cm.
Thompson L. A CASE OF POSSIBLE THIRD INFECTION WITH SYPHILIS. JAMA. 1923;81(25):2114. doi:10.1001/jama.1923.26510250003011b
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