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September 26, 1925


Author Affiliations

Gladys Henry Dick, M.D., Chicago.

JAMA. 1925;85(13):996. doi:10.1001/jama.1925.02670130058029

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To the Editor:  —Since we described a skin test for susceptibility to scarlet fever and preventive immunization of susceptible persons with the sterile toxin, and the corresponding antitoxin for therapeutic and prophylactic treatment, various commercial biologic concerns have been producing the toxin. Some have also been distributing serums under the label of "Scarlet Fever Streptococcus Antitoxin."On inquiry and testing, we found that much of the toxin was made from broth to which considerable amounts of horse blood had been added, thus introducing, quite unnecessarily, the possibility of sensitizing to horse serum during the course of preventive immunization with the toxin. Some preparations of the toxin were not standardized with sufficient accuracy to give dependable results; and most of the toxin was put out in doses too small to produce satisfactory immunization in many susceptible persons.Much of the serum sold as scarlet fever streptococcus antitoxin was put out in

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