In recent years, carcinoma of the extremities has found only a small place in the English surgical literature. This is partially explained by the fact that it is often seen in persons generally otherwise incapacitated, that its diagnosis can frequently be made by inspection, and that it generally necessitates a mutilating operation for its cure.
All these facts apply especially to malignant changes that take place in chronic varicose ulcers, and from the surgical standpoint they are, indeed, mere curiosities. Viewed from the standpoint of the cancer research worker, this material assumes an interest of a large human experiment carried out for years on large numbers of persons with only the very infrequent result that a carcinoma appear; and so unusual is it that one hesitates to consider it as a result of the ulceration.
The epitheliomas, more frequently than other types of malignant disease, seem to be incited to
KNOX LC. EPITHELIOMA AND THE CHRONIC VARICOSE ULCER. JAMA. 1925;85(14):1046–1051. doi:10.1001/jama.1925.02670140032009
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