The study of tryparsamide as an agent for the treatment of trypanosomiasis and syphilis is now approaching a decisive stage, having passed successively through a period of laboratory investigation and a period of preliminary clinical investigation. The results that have been reported on the one hand by Pearce,1 by Chesterman2 and by Smillie,3 and on the other by Lorenz, Loevenhart, Bleckwenn and Hodges,4 and by Moore, Robinson and Keidel,5 supplemented by numerous personal reports from still other clinicians, leave little doubt that, used with discrimination, tryparsamide will prove valuable in the treatment of human and animal trypanosomiasis and of certain forms of syphilis.
Thus far, each step in the progress of these investigations, from the synthesis of the drug to its application to the treatment of diseases, has proceeded as a logical development, based at first on pure experimental evidence and later on clinical experience
BROWN WH, PEARCE L. TRYPARSAMIDE: ITS ACTION AND USE. JAMA. 1924;82(1):5–9. doi:10.1001/jama.1924.02650270009002
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: