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October 10, 1925


JAMA. 1925;85(15):1140-1141. doi:10.1001/jama.1925.02670150038016

The United States Pharmacopeia and the National Formulary contain sixty-four preparations of iron. The chemical fate and the therapeutic efficiency of medicinaliron, nevertheless, have long been uncertain, and debate has been proportionately voluminous. Cushny4 well sums up what is known of the fate of medicinal iron preparations in the body, pointing out that they probably undergo changes in the stomach and then pass into the duodenum, from which the great bulk is carried on into the lower parts of the intestine. Some of the iron is absorbed by the epithelium and leukocytes in solid form and perhaps in solution and then is deposited in the spleen, where it may undergo some changes in form before being taken up by the blood and deposited in the liver and perhaps in the bone marrow. Cushny says:

Where the supply of iron has been inadequate for the formation of hemoglobin, the originally