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Article
January 19, 1924

THE USE OF BENZYL BENZOATE IN THE TREATMENT OF ANGINA PECTORIS

JAMA. 1924;82(3):193-196. doi:10.1001/jama.1924.02650290023005
Abstract

I shall make no attempt to give the literature pertaining to the use and action of this particular benzyl ester further than to say that its mode of action, as pointed out by Macht, is to relieve spasm due to contraction of smooth muscle fiber. Hence it has been employed largely in cases of renal colic and of bronchial asthma. So far as I know, the only article dealing with its use in angina pectoris is a paper by Dr. A. B. Spach1 of Chicago. In that paper the author reported six cases in which more or less complete relief followed the administration of the remedy. In one of them the blood pressure was low, 100 systolic, whereas, in the others, varying degrees of hypertension existed.

My attention was first called to the use of benzyl benzoate in Heberden's angina by my office associate, Dr. Bayard Holmes, Jr., who

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