Alkalis play a varying part in the different plans that have been advocated for the medical management of peptic ulcer. They are not used at all in some forms of treatment, while in other forms they are used in small quantities for short periods only. But it has remained for Sippy to work out a thorough, detailed method of using alkalis with ulcer-bearing patients, which is one of the most important parts of his form of treatment. He insists on the necessity of destroying the corrosive, disintegrating and digestive effect of the gastric juice, pointing out that it is best done by continuously neutralizing the free hydrochloric acid with alkalis; for the digestive properties of pepsin are lost in the absence of free acid. It is true that it is not yet known just what part the acidity of the gastric juice plays in the formation or the delayed healing
SHATTUCK HF, ROHDENBURG EL, BOOHER LE. ANTACIDS IN THE MEDICAL MANAGEMENT OF PEPTIC ULCER. JAMA. 1924;82(3):200–203. doi:10.1001/jama.1924.02650290030008
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