Ordinarily, when we speak of prophylactic measures against a syphilitic infection, we mean the application of a 10 per cent. calomel ointment or similar chemical agents that have proved to be very efficacious, but only when employed within about eight hours after cohabitation.
According to investigations by Brown and Pearce at the Rockefeller Institute, who have studied the dissemination of spirochetes in rabbits, it has been shown that these were present in regional lymph nodes in less than forty-eight hours after their inoculation. This fact would tend to show that the use of external prophylactic agents, even when used within a few hours, might be too late to prevent a general infection, which has been known to have occurred in spite of the use of these prophylactics in quite a number of instances.
Michel and Goodman1 advocate the use of arsphenamin in cases in which one of the persons
Rostenberg A. THE PROPHYLACTIC USE OF ARSPHENAMIN. JAMA. 1924;82(3):207. doi:10.1001/jama.1924.26520290002011b
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