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Article
January 19, 1924

"STUDIES ON ISO-AGGLUTININS IN THE BLOOD OF THE NEW-BORN"

JAMA. 1924;82(3):227. doi:10.1001/jama.1924.02650290057028

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Abstract

To the Editor:  —In an article under this title in The Journal, Nov. 24, 1923, Dr. de Biasi made several statements regarding the use of mother's blood in the transfusion of new-born infants, which, we feel, require corroboration. He says:"Mothers may act as donors for their new-born infants without compatibility tests for agglutination and hemolysis."If this is true, either the infant is a universal recipient and can be transfused without preliminary tests not only from his mother but from any individual, or the iso-agglutinins and the isohemolysins in the infant's serum are absent or not fully established. Other observers have noted cross agglutination of mother's and infant's blood.Untoward results may occur when the blood of a mother is transfused into the infant if the two individuals are of incompatible groups, when, first, the agglutinins in the serum of the mother be unusually strong in titer, which is

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