The following methods are employed in the investigation of liver function in man and in animals:
The secretory or excretory functions of the liver can be investigated by biliary fistulas in man and in animals or in acute experiments in animals by collecting the bile direct from the duct. Thus, the chemistry of the bile both in the gallbladder and as directly secreted by the liver has been investigated and is approximately known. The same method yields data with reference to secretagogues that may stimulate production of bile, the relation of foods to bile secretion, and in acute experiments it is possible to study the evacuation mechanisms of the duct and gallbladder systems aside from the production of bile by the liver cells.
In acute experiments it is possible to collect portal and hepatic blood both during digestion and in fasting. This method has yielded important data on the liver
CARLSON AJ. PHYSIOLOGY OF THE LIVER: PRESENT STATUS OF OUR KNOWLEDGE. JAMA. 1925;85(19):1468–1472. doi:10.1001/jama.1925.02670190028007
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