The physiologic changes that occur when the liver is extirpated have been studied for several years in our laboratories. In this paper I shall present briefly a general review of the results of our experiments on the changes in physiologic processes produced by the sudden and complete removal of the liver, and discuss them in relation to the functions of the liver. Although a great many changes have been observed, data concerning the modification of carbohydrate metabolism, protein metabolism and the major constituents of the bile mainly will be presented.
Several different species of animals have been employed in the experiments, such as the goose, the duck, the frog, the turtle and the fish. While the general effects of hepatectomy have been the same in all species of animals, the variation probably depending on the difference in metabolism of the various species, I shall emphasize the results as obtained in
MANN FC. MODIFIED PHYSIOLOGIC PROCESSES FOLLOWING TOTAL REMOVAL OF THE LIVER. JAMA. 1925;85(19):1472–1475. doi:10.1001/jama.1925.02670190032008
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