In the present communication we outline some of the principal results of correlated studies on the functional state of the liver of the lower animals and of man. The studies include both means for ascertaining the state of liver function and means for influencing that state. In man the state of liver function was determined by estimating the concentrations of cholesterol, "bile acids," "total pigments" and "bilirubin" of duodenal contents. These contents were obtained both from normal controls and from patients with various diseases including lesions of the liver or its ducts. The studies on animals will be reported in detail at a later date.
It is well established that the liver performs a number of functions of foremost importance to the economy of the organism. It converts protein products absorbed from the intestines into urea. It detoxifies poisons that come to it from a variety of sources. It excretes
McCLURE CW, MENDENHALL WL, HUNTSINGER ME. THE EVALUATION AND TREATMENT OF DISTURBED LIVER FUNCTION. JAMA. 1925;85(20):1537–1540. doi:10.1001/jama.1925.02670200015005
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