MECHANICAL FACTORS IN THE GENESIS AND PROGRESS OF PULMONARY TUBERCULOSIS
W. A. Gekler, M.D.Beginning with the discovery of tuberculin, followed a few years later by that of diphtheria antitoxin, a great amount of investigation along immunologic lines was done. This field of research led to much valuable information, not merely in medicine generally, but also in tuberculosis. It has had, however, the effect of laying great stress on immunity and resistance in the explanation of tuberculosis in its various forms. The mechanical factors which operated in the lungs, and which are absent in most other important organs, have been more or less generally overlooked.Physiologically, the lungs are not divided into a right and left lung or various lobes, but into an upper and lower portion, the physiologic middle being the attachment of the trachea at its bifurcation to the spine. As Tendeloo1 has shown, the forces that
GEKLER WA, LOVELACE WR, RANKIN HP, WEIGEL BJ. TUBERCULOUS CAVITATION OF THE LUNG: MECHANICAL FACTORS IN ITS GENESIS, AND COMBINED CHEMOTHERAPEUTIC AND SURGICAL TREATMENT. JAMA. 1924;82(6):457–463. doi:10.1001/jama.1924.02650320027009
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