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November 14, 1925

The Nature of Enzyme Action.

JAMA. 1925;85(20):1581. doi:10.1001/jama.1925.02670200059035

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This edition of Bayliss' monograph is organized like the fourth, but includes numerous pertinent references to work published since the preceding edition appeared. New material included in the text amounts, all told, to about ten pages incorporating significant material obtained from approximately forty new contributions to the field. New work reported has strengthened rather than modified Bayliss' general conclusions, which are expressed identically in the fourth and in this edition. Bayliss teaches that enzymes obey the usual laws of catalytic phenomena, particularly in heterogeneous systems in which reactions taking place are essentially at the surfaces of the colloidal enzymes. The author believes that reactions catalyzed by enzymes are reversible, the equilibrium point being determined by the effective concentration of water. In vitro, water necessarily predominates; hence, nearly complete hydrolysis is reached, whereas in vivo there exist mechanisms for the diminution of the effective concentration of water favorable to synthesis.

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