In 1921, Dr. C. C. Haskell and I1 wrote an article on the dangers of pituitary extract which caused quite a disturbance in French medical literature, culminating in a special double number of the Revue française de gynécologie et d'obstétrique,2 devoted entirely to the consideration of the use of hypophysial extract in obstetrics. The 105 pages of the issue are taken up chiefly with various men's ideas as to the modes of administration (subcutaneous or intravenous), the dosage, the indications and contraindications, and the explanation of the maternal and fatal catastrophes. (It is admitted that some have occurred.) Laurentie has two pages in which he reports a disaster. He makes the point, a very good one, that uterine inertia may be associated with muscular degeneration. If Couvelaire's reply to the editor's questionnaire3 had been put in a conspicuous place, say as an introduction, instead of in fine
RUCKER MP. THE ACTION OF PITUITARY EXTRACT ON THE UTERUS. JAMA. 1925;85(21):1637–1638. doi:10.1001/jama.1925.02670210039012
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