The chief manifestation of pernicious anemia is, of course, the increased destruction of red blood corpuscles; but there are also changes in other parts of the body, notably in the nervous system and the alimentary tract. The natural assumption is that the blood changes, the gastro-intestinal symptoms and the nervous lesions are dependent on one another in some way. Their frequent association in pernicious anemia rather than in other forms of anemia has seemed to many clinicians to favor the view that they are the result of a common cause that makes the pernicious malady a well defined entity.
Through the veil of obscurity that has so long enshrouded the origin of pernicious anemia, investigators have attempted in particular to discover an etiologic intoxication or infection as the most probable pathogenic agency. True, some students of the subject have preferred to point to the red corpuscle as the foremost factor
PERNICIOUS ANEMIA. JAMA. 1925;85(21):1644–1645. doi:10.1001/jama.1925.02670210046017
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