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November 28, 1925


JAMA. 1925;85(22):1742-1743. doi:10.1001/jama.1925.02670220060026

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Symmetric Cyanoderma  Dr. Moreira da Fonseca has reported to the National Academy of Medicine what he considers a case showing a new syndrome, related to the sympathetic system. He has suggested the name of symmetric cyanoderma. His case was in a boy, 14 years old, who had been treated for malaria. The physical development was normal, but the skin exhibited symmetrically distributed dark blue spots. These did not yield to pressure, nor did exercise produce any change in them. No secretory or trophic changes were noted, not modifications in sensitiveness or temperature. The spots were located in the face, where they seemed darker, the chin, ears, trunk, breasts, arms and legs, but always exhibiting a symmetrical arrangement. After a short period, they became yellowish red, the change starting in the center. The shape varied, being either round, elliptic or annular, and occasionally forming large patches resembling old ecchymoses. There were

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