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Article
November 28, 1925

THE ACIDIFICATION OF GASTRIC CONTENTS IN DETERMINING NEUTRAL RED EXCRETION

JAMA. 1925;85(22):1748. doi:10.1001/jama.1925.02670220066033

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Abstract

To the Editor:  —In Winkelstein and Marcus' recent article "The Excretion of Neutral Red into the Human Stomach" (The Journal, October 31, p. 1397) they reported that they failed to recover neutral red in the gastric contents of some cases of achylia gastrica other than pernicious anemia. According to the method they used, "the patients presented themselves with a fasting stomach; the Rehfuss tube was passed, and 2 c.c. of a 1 per cent, solution of neutral red (Ehrlich's neutral red was freshly dissolved in distilled water and boiled) was injected intramuscularly in the gluteal region. The gastric contents were aspirated every two minutes until the dye appeared as a definite pink discoloration." In our recent publication (The Journal, September 12, p. 794) we pointed out the fallacy of looking for pinkish coloration in cases with anacidity, unless the contents are brought to a hydrogen ion concentration sufficiently acid to

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