In our first paper on mercurochrome-220 soluble,1 experiments were cited to show that it could be introduced intravenously in doses of 5 mg. per kilogram of body weight in rabbits and 10 mg. per kilogram in dogs, with impunity. In this paper we detailed a prolonged search which we had made with many old and new combinations of mercury and of dyes to find a germicide which would not coagulate albumin and was nontoxic. We showed that mercurochrome answered these requirements and could be used in wounds in a 1 per cent, solution. Our toxicity experiments were confirmed by Piper2 on both animals and human subjects. His clinical results have been most striking. Later it was shown in our laboratories, by Hill and Colston3 that, after the intravenous administration of 1, 2.5, 5 and 10 mg. per kilogram of mercurochrome to normal rabbits, the urine became either
YOUNG HH, HILL JH. THE TREATMENT OF SEPTICEMIA AND LOCAL INFECTIONS: BY INTRAVENOUS INJECTIONS OF MERCUROCHROME-220 SOLUBLE AND OF GENTIAN VIOLET. JAMA. 1924;82(9):669–675. doi:10.1001/jama.1924.02650350001001
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