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Accidents Attributed to B C G Vaccine
The announcement that grave accidents had occurred in Lübeck, Germany, as a result of the use of the B C G vaccine to combat tuberculosis caused deep regret throughout Europe. Of 246 children who had received the vaccine, it was stated that eight had died and that twenty-five were ill. Mr. Calmette and Mr. Guérin, who were immediately interviewed, sent a delegation to Lübeck from the Pasteur Institute in Paris, to make an investigation, for it was thought that an error in diagnosis and some disease other than tuberculosis might be involved. Attention was called to the peculiar fact that, of the large number of children who were vaccinated, only 12 per cent had become ill and not all of them. Furthermore, aside from the eight who died, all the other children who were ill recovered rapidly, which seems improbable if the disease
PARIS. JAMA. 1930;95(2):138–139. doi:10.1001/jama.1930.02720020054022