Under the term adenoma, there is described in the literature two definite distinct pathologic entities, adenomatosis, or the diffuse adenomatous goiter, and true adenoma, which is a definite encapsulated growth beginning from a single point and answering all the requirements of the benign tumors.
Adenomatosis of the thyroid is characterized by a diffuse new formation of acini usually involving the entire thyroid gland, beginning with the fetal type without secretion, but later assuming the adult or colloid type, and giving rise to no symptoms at first, but later to those of pure hyperthyroidism.
Wilson, in 1913, briefly described this condition and applied the term adenomatosis. Goetsch, in 1920 and 1921, described the early stage under the term diffuse adenomatosis, but referred to the new formation of acini as "an abortive attempt at the formation of young small alveoli." Plummer, in his writings, has grouped adenomatosis with the adenomas, treating them
ELSE JE. ADENOMATOSIS, OR THE DIFFUSE ADENOMATOUS GOITER. JAMA. 1925;85(24):1878–1882. doi:10.1001/jama.1925.02670240030009
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