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Article
March 8, 1924

METASTATIC BASAL CELL CARCINOMA FROM THE SKIN: REPORT OF TWO CASES

JAMA. 1924;82(10):775-778. doi:10.1001/jama.1924.02650360017005
Abstract

Basal cell epitheliomas, whether of the "rodent ulcer" or other "superficial" type, are well known to be capable of considerable local tissue destruction—indeed, even capable of destroying adjacent cartilage, bone and other deep tissues; but truly metastatic new growths resulting from them are almost unheard of. This type of epithelial growth is known to involve freely the lymph spaces of the corium, but is generally believed incapable of traversing the lymph channels and invading the lymphatic glands. My principal object here is to report two cases that seem unquestionably to present the anomaly.

CASES REPORTED IN THE LITERATURE  In the literature have been found the following similar instances, but in each, with the exception of the first case mentioned, the data offered are not conclusive proof of similarity.Beadles1 reports the case of a man who died at 46 years of age from septic pneumonia, the result of absorption

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