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Article
December 26, 1925

THE TREATMENT OF ERYTHREMIA WITH PHENYLHYDRAZIN: TREVOR OWEN, M.B. BALTIMORE

JAMA. 1925;85(26):2027-2032. doi:10.1001/jama.1925.02670260025010
Abstract

In a previous paper,1 a case of polycythemia was reported which had been under treatment with phenylhydrazin hydrochlorid. Since the result in that case was so satisfactory, and since none of the other methods of treatment for this disease have been more than temporarily beneficial, it seems desirable to record the observations in four more cases treated with this drug in order that its actual value may be finally estimated. As I pointed out in the first paper, phenylhydrazin was used by Morowitz and Pratt to produce secondary anemia in animals, after which Eppinger suggested its use in the treatment of erythremia. Later, Taschenberg experimented with the drug in one patient. The results obtained in their cases were not successful, probably because the patients were in a late stage of the disease.

If phenylhydrazin proves of benefit in the treatment of the disease, it is important, because by the

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