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December 26, 1925


Author Affiliations

Acting Director, Department of Pharmacology, Marquette University School of Medicine.

JAMA. 1925;85(26):2049. doi:10.1001/jama.1925.02670260047027

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To the Editor:  —In The Journal, November 7, appeared an article by Dr. Gwathmey which he describes as a reply to my work on the alleged synergism of magnesium sulphate and morphin. There are three tables. Table 1 furnishes data of a case in which the patient experienced greater relief from pain when given morphin plus magnesium sulphate than when given morphin alone. This mere fact does not, however, constitute proof that simple addition did not bring about this result; indeed, the second longest period of relief was experienced in one of the two instances only in which magnesium sulphate alone was used. Tables 2 and 3 comprise lists of cases in which the time before postoperative sedative was shown to be longer when morphin plus magnesium sulphate was used preoperatively than when morphin was used alone. Here again there is no evidence of synergism. Both experimental and clinical literature

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