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It has been generally assumed by recent investigators that pernicious anemia is associated with an extensive destruction of red blood corpuscles, and certain features of the disease, such as the high bilirubin content of the serum, which manifests itself in the characteristic yellow tint of the skin and conjunctivae, support such a view strongly. As it is obvious that an understanding of the mechanism of this blood destruction would be an important step in advancing our knowledge of this mysterious disease, many attempts have been made to discover the nature of the underlying process. Up to the present, however, there appears to be no commonly accepted explanation.
The subject has been approached most frequently by attempts to find hemolytic toxins in the blood serum or to determine alterations in the fragility of the erythrocytes, but the results in these fields have not proved to be definitely significant. It has therefore
PEABODY FW, BROUN GO. PHAGOCYTOSIS OF ERYTHROCYTES IN PERNICIOUS ANEMIA: PRELIMINARY NOTE. JAMA. 1924;82(12):963. doi:10.1001/jama.1924.02650380031011
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