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Article
March 22, 1924

AGGLUTINATION IN GONOCOCCUS INFECTION WITH CONCENTRATED SERUM

Author Affiliations

Chicago
From the John McCormick Institute for Infectious Diseases.

JAMA. 1924;82(12):964-965. doi:10.1001/jama.1924.26520380002012b
Abstract

The serum of patients with gonococcus infection does not contain, as a rule, agglutinins in sufficient quantity to make the agglutination test of any practical value as an aid in diagnosis. I1 have found that the arachnoid fluid and serum of syphilitic patients give a more sensitive test when concentrated. The euglobulin and lower pseudoglobulins, obtained by adding saturated solution of ammonium sulphate to the serum, were redissolved in physiologic sodium chlorid solution in a fractional quantity of the original serum. This method of concentration was applied to two antigonococcus rabbit serums made by injecting the Torrey and Buckell2 gonococcus Strain 34, which has been found to be one of the most widely generalized strains of gonococcus as classified by agglutination and absorption, since it gave clear-cut absorption of agglutinin from twenty-four of twenty-seven monovalent antigonococcus serums. The results of concentration of these two antigonococcus serums are given in

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