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Article
March 29, 1924

A STUDY OF NEOCINCHOPHEN IN THE TREATMENT OF RHEUMATIC FEVER

Author Affiliations

NEW YORK
From the Hospital of the Rockefeller Institute for Medical Research.

JAMA. 1924;82(13):1028-1036. doi:10.1001/jama.1924.02650390018008
Abstract

In recent years, several favorable reports have appeared on the use of cinchophen (phenylcinchoninic acid) and its derivatives in the treatment of arthritis. Originally recommended as uric acid eliminants in gout, these drugs were found to be effectual in the relief of the polyarthritis and pyrexia of rheumatic fever. One of the derivatives, the ethyl ester of para-methylphenylcinchoninic acid,1 besides having antirheumatic properties equivalent to those of phenylcinchoninic acid, has the additional advantage of being tasteless and nonirritating to the stomach.

In a study of rheumatic fever, carried on for several years, we had already made detailed records of the effect of salicyl derivatives on certain symptoms of this disease, and therefore were in a position to compare the newer drug with the older. This communication is a report of these studies made during the last three years.

REVIEW OF LITERATURE  Heller,2 Bendix,3 Klemperer 4 and

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