Extensive carcinomatous involvement of the mouth and cheek presents many difficulties in treatment. Particularly is this true if the malignant growth presses on the sensory nerves in this area. Even if pain is not a prominent factor before treatment is begun, it is sure to be severe afterward. If extensive resections are attempted with the thermocautery, if radium needles or tubes are inserted, or if intensive roentgen-ray exposure is used, the reaction set up is almost inevitably painful. The pain is constant, night and day, without remission. It may not be severe, but because it is ever-present, the sufferer's morale is slowly broken down, he dreads the necessary inspections and manipulation of his wound, and he becomes increasingly difficult to treat. Nowadays, with the educational campaign carried on against cancer, the general public is well informed as to its manifestations and prognosis. Cancer about the oral cavity is a filthy
GRANT FC. RELIEF FOR THE PAIN IN CARCINOMA OF THE FACE. JAMA. 1926;86(3):173–176. doi:10.1001/jama.1926.02670290013004
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