This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
To the Editor:
—In The Journal, Nov. 17 and Nov. 24, 1923, Dr. Simon Flexner, in an article on epidemic encephalitis and allied conditions, casts doubts on much of the experimental work that has appeared on this disease. His references to my own work do not give a true interpretation of the results achieved. For example, he states that:Another reputed successful transmission directly to monkeys is reported by McIntosh and Turnbull. This example can be dealt with briefly since the brain of a fatal human case was placed entire in 33 per cent, glycerol, where it remained for fourteen days before portions of the much softened organ were removed for the making of a Berkefeld filtrate, which was used for intracerebral injection. The inoculated animal had a convulsion six days later, and died nearly two months after the injection. Perivascular lesions were present in the optic thalamus, but their
McIntosh J. EPIDEMIC ENCEPHALITIS. JAMA. 1924;82(13):1065. doi:10.1001/jama.1924.02650390055033
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: