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March 29, 1924


Author Affiliations

London, England. Professor of Pathology, University of London.

JAMA. 1924;82(13):1065. doi:10.1001/jama.1924.02650390055033

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To the Editor:  —In The Journal, Nov. 17 and Nov. 24, 1923, Dr. Simon Flexner, in an article on epidemic encephalitis and allied conditions, casts doubts on much of the experimental work that has appeared on this disease. His references to my own work do not give a true interpretation of the results achieved. For example, he states that:Another reputed successful transmission directly to monkeys is reported by McIntosh and Turnbull. This example can be dealt with briefly since the brain of a fatal human case was placed entire in 33 per cent, glycerol, where it remained for fourteen days before portions of the much softened organ were removed for the making of a Berkefeld filtrate, which was used for intracerebral injection. The inoculated animal had a convulsion six days later, and died nearly two months after the injection. Perivascular lesions were present in the optic thalamus, but their

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