It is estimated that the human kidney contains two million glomeruli, or urine-forming units. For each of these there is a tubule. Richards1 commented, in a lecture before the Harvey Society in 1921, on the tacit assumption in the great bulk of writing on kidney function that the circulation through all these units is at least roughly uniform, and that they take equal part in the sum of activities which make up the total function of the whole organ. He pointed out, on the other hand, that as early as 1859 Hermann noted that the two kidneys may eliminate different amounts of urine, and he stated that it was simplest to assume that not all parts of the kidney act to the same degree all the time, and that one part of the excreting surface may rest or be active, while another part is in reserve.
Such a conception
THE GLOMERULAR CIRCULATION OF THE KIDNEY. JAMA. 1926;86(3):201–202. doi:10.1001/jama.1926.02670290041019
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