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January 23, 1926


JAMA. 1926;86(4):257-261. doi:10.1001/jama.1926.02670300019005

A general impression has probably existed in the minds of the profession ever since medical arts have been practiced that neoplasms could result from trauma. Virchow subscribed to this and rather clarified conceptions concerning tumor development by proposing as a doctrine of pathology that any change which is associated with tissue proliferation may terminate in the development of a true tumor. In some instances involving undetermined factors and conditions, this change occurs more readily than in others. The more active tissues are proliferating, and the longer proliferation continues to occur the more readily neoplasms develop. The transformation from hyperplasia to neoplasm, more especially malignant neoplasm, is of course a relatively rare occurrence, while simple hyperplasia from many causes is exceedingly common.

We know that whereas traumas of various sorts are of almost daily occurrence in every human life, malignancy is rare, and that trauma can never be the only and