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January 23, 1926


JAMA. 1926;86(4):267-268. doi:10.1001/jama.1926.02670300029010

In view of Neugebauer's report1 on the hypo-acidity found in syphilitic persons, it was thought that an examination of the gastric acidity in a group of syphilitic children might prove interesting. The German observer found in a group of 200 syphilitic recruits from 20 to 25 years of age that, before treatment was carried out, 62 per cent. manifested hypo-acidity, 18 per

cent. anacidity and 17 per cent. hyperacidity. In general, he found a persistent hypo-acidity to the point of achylia. Neugebauer offers the explanation that the lowered acidity is due to a change in the tonus of the vagus, a direct disease of the mucosa or a combination of these factors. He attributes the cases of hyperacidity to a temporary phase preliminary to the ultimate anacidity.

In our investigation, twenty-one children, from 4 to 13 years of age, with positive Wassermann reactions, who were under treatment with neo-arsphenamin