Upsets in the heat-regulating devices of the body are among the disturbances of which the physician is compelled most frequently to take cognizance. They are usually distressing to the patient, and frequently disconcerting to the practitioner. Although the use of antipyretics to combat fever has been placed on a far more rational basis than that on which it rested fifty years ago, it cannot be regarded as much more than a sort of scientific empiricism, even today. In discussing the significance of fever, before the Harvey Society, a few years ago, MacCallum 1 remarked that the term is one so honored by age and by the good that must consequently inhere in it that it cannot be discarded or dismembered. It is difficult, nevertheless, to define this conception clearly, because even yet we are unable to say with certainty at what point the direct effects of the cause of the
HEAT REGULATION AND WATER EXCHANGE. JAMA. 1924;82(15):1200. doi:10.1001/jama.1924.02650410042017
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