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Article
January 30, 1926

ABSCESS FOLLOWING THE INTRAMUSCULAR INJECTION OF BISMUTH METAL (NEOTREPOL)

JAMA. 1926;86(5):346. doi:10.1001/jama.1926.26720310001009

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Abstract

Cysts and nodules are not uncommon following the deep intramuscular injection of the salts of heavy metals, but this is the first case so far as is known in which an injection of bismuth metal has produced an abscess.

This product was first prepared in France by Sazerac and Levaditi, who obtained bismuth metal in a fine state of division by the reduction of a bismuth salt. The bismuth is then held in suspension in a 10 per cent dilution of an isotonic solution. The therapeutic dose is from 0.15 to 0.20 Gm. of the drug, administered in a series of from ten to twelve injections, and is given twice a week.

REPORT OF CASE 

History.  —A married woman, aged 18, had been infected by her husband four weeks before examination. When seen, she had a rather large initial lesion on the left labium majus, and shotty inguinal glands. She

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