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January 30, 1926


JAMA. 1926;86(5):351-352. doi:10.1001/jama.1926.02670310033013

At present the preponderance of opinion with respect to the parathyroid structures makes them responsible for the elaboration of a hormone having to do normally with the regulation of calcium metabolism through a specific control of the concentration of the element in the circulating blood.1 This view has been rendered highly plausible by the recent well substantiated demonstrations of the preparation of extracts from the parathyroid tissue that have the potency of raising the concentration of the circulating calcium. They are effective in replacement therapy after the otherwise fatal complete parathyroidectomy. Parathyroid tetany and a low level of blood calcium have long been recognized as coincident phenomena. Both can be respectively relieved and raised by administration of calcium salts; likewise by the use of preparations containing the parathyroid hormone.

As might be expected, such experimental studies in this field have promptly given an impetus to the discovery of possible