Since Hall1 proposed about two years ago the use of carbon tetrachlorid for the removal of hookworms harbored in human beings, this substance has been generally recognized as an effective anthelmintic, and is extensively employed for combating hookworm disease in tropical regions. The results have been, in general, better than those with any other drug that has heretofore been used for the same purpose.
Effective as it is, the use of this drug is not always unaccompanied by certain ill effects. There have already been a number of cases reported showing the toxic property of this drug, manifested in ways varying from a mild, transient attack of dizziness, headache and nausea to such severe symptoms as fever, pain, vomiting, or even convulsions and death.
Clinically there is a great deal of individual variation in the reaction to the drug. Many persons show no ill after-effects whatever, others show mild
PHELPS BM, HU CH. CARBON TETRACHLORID POISONING: REPORT OF TWO FATAL CASES AND A SERIES OF ANIMAL EXPERIMENTS. JAMA. 1924;82(16):1254–1256. doi:10.1001/jama.1924.02650420018010
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