There are patients with syphilis who show only a slight reduction in the Wassermann reaction under the usual drug therapy. As the Wassermann test is considered the most important criterion of the benefit of treatment in latent and inactive syphilis, this type of patient is classified as resistant or Wassermann-fast. The serologic reaction, however, must not be taken as the only test of cure.
An analysis was made during the World War of a series of patients who had been given the routine treatment of neo-arsphenamin intravenously and mercurial oil intramuscularly. The patients were adult males in the same age period, with similar conditions of life, and would seem to be a particularly good control group, since they received regular and routine series of injections. As indicated in Table 1, the best results
were had in the class diagnosed early by a positive dark field while the Wassermann test was
HERROLD RD. PROTEIN AS AN ADJUNCT IN THE TREATMENT OF RESISTANT SYPHILIS. JAMA. 1926;86(6):413–414. doi:10.1001/jama.1926.02670320027009
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