LOCAL APPLICATIONS TO MUCOUS MEMBRANES
Applications to mucous membranes have to deal with water-soaked surfaces of great absorbing capacity for aqueous solutions, but insusceptible of penetration by oily liquids, unless these are volatile. Hence, as a general proposition—to which there are exceptions— aqueous rather than oily liquids are used as applications to mucous membranes because these membranes shed oil as the skin sheds water.As living cells cover mucous membranes, agents that would be tolerated without detriment by the dead, horny surface of the skin may kill or severely injure mucous membranes. The various membranes differ among themselves in sensitiveness. The following general rule might be of some help to beginners, though it has many exceptions, chief among which is the nature of the medicament. The strength of lotions may, in general, be 1 per cent. This strength may be doubled for applications to the mouth or the
FANTUS B. THE TECHNIC OF MEDICATIONA SERIES OF ARTICLES ON THE METHODS OF PRESCRIBING AND PREPARING, THE INDICATIONS FOR, AND THE USES OF VARIOUS MEDICAMENTS. JAMA. 1926;86(7):483–485. doi:10.1001/jama.1926.26720330002010a
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