The uniformly favorable results obtained by Young and Hill1 in the treatment of acute septicemia by the use of dyes have attracted the attention of clinicians and have led to a more extensive use of dyes in the treatment of septicemia and also in local infection. The results obtained with the dyes are not uniformly encouraging; in fact, unfavorable results are being reported with sufficient frequency to check the development of dye therapy. It may be advisable, at this time, to call a halt to the indiscriminate use of dyes until the treatment has been standardized. However, the case against the dyes is not so much that they contribute to the course of the infection as that they fail to check it in an unknown percentage of cases. Toxic results occasionally follow the intravenous injection of dyes, particularly mercurochrome-220 soluble.2 It is evident that much experimental work, both
BURKE V, NEWTON JL. PREPARATION OF GENTIAN VIOLET SOLUTIONS FOR INTRAVENOUS INJECTION. JAMA. 1926;86(8):529–534. doi:10.1001/jama.1926.02670340007003
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