Pemberton1 noted that patients with chronic arthritis seemed to improve when they were given diets low in carbohydrate, and were made worse by diets high in carbohydrate. From this he concluded that patients with diabetes should be comparatively free from arthritis because of the fact that their disturbed metabolism of sugar demanded prolonged diets low in carbohydrate. In his own experience, and in that of Allen and Joslin, diabetes and arthritis only rarely were associated. This has not, however, been our experience. During the last year at the Mayo Clinic, we have seen 474 patients with diabetes; fifty-one of these (10.8 per cent) who had well defined but, as a rule, comparatively mild diabetes had arthritis. They were all given a diet in which the available glucose did not exceed 140 Gm., and were kept in the hospital under careful supervision for at least two weeks on their first
SCHMITT EOG, ADAMS SF. THE ASSOCIATION BETWEEN DIABETES MELLITUS AND CHRONIC INFECTIOUS ARTHRITIS. JAMA. 1926;86(8):535–536. doi:10.1001/jama.1926.02670340013005
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