Necrosis in the chancre takes place at the expense of newly formed tissue elements, while the chancroid destroys the normal fixed structures of the parts affected. The soft chancre, therefore, is a true ulcer. It is a process of infiltration and tissue suppuration with necrotic material covering the area of dissolution, and it is this covering that renders local application of antiseptics of little value.
There is no need to recount here the failures of the usual agents in treatment. The cautery and caustics, as a class, have been the most serviceable, because they go beyond the protective coverings to the base of the sore. But ordinary caustics destroy normal tissues as readily as those which are pathologic, so that repeated applications result in a deepening and widening of the ulcer, and make it impossible to utilize the germicidal properties that caustics possess. Relapse from auto-inoculation is a problem.
RUPEL E. CHANCROIDAL ULCERS TREATED LOCALLY WITH ANTIMONY AND POTASSIUM TARTRATE SOLUTIONSREPORT OF EIGHT CASES. JAMA. 1926;86(8):544–545. doi:10.1001/jama.1926.02670340022008
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